Remisión progresiva de antidiabéticos en pacientes obesos sometidos a cirugía bariátrica
DOI:
https://doi.org/10.56048/MQR20225.8.1.2024.2418-2438Palabras clave:
Cirugía Bariátrica; Diabetes Tipo 2; Remisión de Diabetes; Antidiabéticos; ObesidadResumen
Introducción: La cirugía bariátrica se ha establecido como un procedimiento eficaz para el manejo del sobrepeso y enfermedades asociadas, especialmente la diabetes tipo 2 (DM2). La vinculación entre la cirugía bariátrica y la remisión de la diabetes ha ganado atención en la comunidad médica.
Objetivo: Determinar la eficacia de la cirugía bariátrica en la remisión progresiva de la necesidad de antidiabéticos en pacientes obesos con diabetes tipo 2.
Metodología: Se realizó una revisión bibliográfica exhaustiva, seleccionando estudios que abordan la cirugía bariátrica y su impacto en pacientes diabéticos obesos. Se incluyeron estudios longitudinales y transversales que reportan datos pre y postoperatorios.
Resultados: Los estudios indican una significativa remisión de diabetes tipo 2 post-cirugía bariátrica, con una notable reducción o eliminación del uso de antidiabéticos. La remisión varía según el tipo de cirugía, siendo más notable en técnicas como el bypass gástrico y la gastrectomía en manga.
Conclusiones: La cirugía bariátrica evidencia ser una opción eficiente para la reducción de la DM 2 en individuos obesos, reduciendo significativamente la necesidad de medicación antidiabética. Esto subraya la importancia de considerar este procedimiento quirúrgico en la terapéutica de individuos con DM 2 con obesidad.
Descargas
Métricas
Cited
DOI: 10.56048
Citas
Affinati, A. H., Esfandiari, N. H., Oral, E. A., & Kraftson, A. T. (2019). Bariatric surgery in the treatment of type 2 diabetes. Current diabetes reports, 19, 1-10. https://link.springer.com/article/10.1007/s11892-019-1269-4
Aminian, A., Zajichek, A., Arterburn, D. E., Wolski, K. E., Brethauer, S. A., Schauer, P. R., ... & Nissen, S. E. (2019). Association of metabolic surgery with major adverse cardiovascular outcomes in patients with type 2 diabetes and obesity. Jama, 322(13), 1271-1282. https://jamanetwork.com/journals/jama/article-abstract/2749478
Arterburn, D. E., Telem, D. A., Kushner, R. F., & Courcoulas, A. P. (2020). Benefits and risks of bariatric surgery in adults: a review. Jama, 324(9), 879-887. https://jamanetwork.com/journals/jama/article-abstract/2770015
Batterham, R. L., & Cummings, D. E. (2016). Mechanisms of diabetes improvement following bariatric/metabolic surgery. Diabetes care, 39(6), 893-901. https://diabetesjournals.org/care/article/39/6/893/29560/Mechanisms-of-Diabetes-Improvement-Following
Browning, M. G., Mazzini, G. S., Wolfe, L., Kaplan, A., Khoraki, J., & Campos, G. M. (2020). Factors mediating type 2 diabetes remission and relapse after gastric bypass surgery. Journal of the American College of Surgeons, 230(1), 7-16. https://www.sciencedirect.com/science/article/abs/pii/S1072751519321155
Buchwald, H., & Buchwald, J. N. (2019). Metabolic (bariatric and nonbariatric) surgery for type 2 diabetes: A personal perspective review. Diabetes Care, 42(2), 331–340. https://doi.org/10.2337/dc17-2654
Courcoulas, A. P., Gallagher, J. W., Neiberg, R. H., Eagleton, E. B., DeLany, J. P., Lang, W., ... & Jakicic, J. M. (2020). Bariatric surgery vs lifestyle intervention for diabetes treatment: 5-year outcomes from a randomized trial. The Journal of Clinical Endocrinology & Metabolism, 105(3), 866-876. https://academic.oup.com/jcem/article/105/3/866/5699613
Cummings, D. E., & Rubino, F. (2018). Metabolic surgery for the treatment of type 2 diabetes in obese individuals. Diabetologia, 61(2), 257-264. https://link.springer.com/article/10.1007/s00125-017-4513-y
English, W. J., & Williams, D. B. (2018). Metabolic and bariatric surgery: an effective treatment option for obesity and cardiovascular disease. Progress in Cardiovascular Diseases, 61(2), 253-269. https://www.sciencedirect.com/science/article/abs/pii/S003306201830121X
Evers, S. S., Sandoval, D. A., & Seeley, R. J. (2017). The physiology and molecular underpinnings of the effects of bariatric surgery on obesity and diabetes. Annual Review of Physiology, 79, 313-334. https://www.annualreviews.org/doi/full/10.1146/annurev-physiol-022516-034423
Fisher, D. P., Johnson, E., Haneuse, S., Arterburn, D., Coleman, K. J., O’Connor, P. J., ... & Sidney, S. (2018). Association between bariatric surgery and macrovascular disease outcomes in patients with type 2 diabetes and severe obesity. Jama, 320(15), 1570-1582. https://jamanetwork.com/journals/jama/article-abstract/2707461
Flynn, C. R., Albaugh, V. L., & Abumrad, N. N. (2019). Metabolic effects of bile acids: potential role in bariatric surgery. Cellular and Molecular Gastroenterology and Hepatology, 8(2), 235-246. https://www.sciencedirect.com/science/article/pii/S2352345X19300591
Jans, A., Näslund, I., Ottosson, J., Szabo, E., Näslund, E., & Stenberg, E. (2019). Duration of type 2 diabetes and remission rates after bariatric surgery in Sweden 2007–2015: A registry-based cohort study. PLoS medicine, 16(11), e1002985. https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1002985
Jehan, S., Myers, A. K., Zizi, F., Pandi-Perumal, S. R., Jean-Louis, G., & McFarlane, S. I. (2018). Obesity, obstructive sleep apnea and type 2 diabetes mellitus: Epidemiology and pathophysiologic insights. Sleep medicine and disorders: international journal, 2(3), 52. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6112821/
Khorgami, Z., Shoar, S., Saber, A. A., Howard, C. A., Danaei, G., & Sclabas, G. M. (2019). Outcomes of bariatric surgery versus medical management for type 2 diabetes mellitus: a meta-analysis of randomized controlled trials. Obesity surgery, 29, 964-974. https://link.springer.com/article/10.1007/s11695-018-3552-x
Koliaki, C., Liatis, S., Le Roux, C. W., & Kokkinos, A. (2017). The role of bariatric surgery to treat diabetes: current challenges and perspectives. BMC endocrine disorders, 17, 1-12. https://link.springer.com/article/10.1186/s12902-017-0202-6
Laursen, T. L., Hagemann, C. A., Wei, C., Kazankov, K., Thomsen, K. L., Knop, F. K., & Grønbæk, H. (2019). Bariatric surgery in patients with non-alcoholic fatty liver disease-from pathophysiology to clinical effects. World journal of hepatology, 11(2), 138. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6393715/
Leitner, D. R., Frühbeck, G., Yumuk, V., Schindler, K., Micic, D., Woodward, E., & Toplak, H. (2017). Obesity and type 2 diabetes: two diseases with a need for combined treatment strategies-EASO can lead the way. Obesity facts, 10(5), 483-492. https://karger.com/ofa/article/10/5/483/240906/Obesity-and-Type-2-Diabetes-Two-Diseases-with-a
Liu, H., Hu, C., Zhang, X., & Jia, W. (2018). Role of gut microbiota, bile acids and their cross‐talk in the effects of bariatric surgery on obesity and type 2 diabetes. Journal of diabetes investigation, 9(1), 13-20. https://onlinelibrary.wiley.com/doi/full/10.1111/jdi.12687
Madsen, L. R., Baggesen, L. M., Richelsen, B., & Thomsen, R. W. (2019). Effect of Roux-en-Y gastric bypass surgery on diabetes remission and complications in individuals with type 2 diabetes: a Danish population-based matched cohort study. Diabetologia, 62, 611-620. https://link.springer.com/article/10.1007/s00125-019-4816-2
Miras, A. D., Kamocka, A., Patel, D., Dexter, S., Finlay, I., Hopkins, J. C., ... & Welbourn, R. (2018). Obesity surgery makes patients healthier and more functional: real world results from the United Kingdom National Bariatric Surgery Registry. Surgery for Obesity and Related Diseases, 14(7), 1033-1040. https://www.sciencedirect.com/science/article/pii/S1550728918300911
Park, J. Y. (2018). Prediction of type 2 diabetes remission after bariatric or metabolic surgery. Journal of Obesity & Metabolic Syndrome, 27(4), 213. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513303/
Peterli, R., Wölnerhanssen, B. K., Peters, T., Vetter, D., Kröll, D., Borbély, Y., ... & Bueter, M. (2018). Effect of laparoscopic sleeve gastrectomy vs laparoscopic Roux-en-Y gastric bypass on weight loss in patients with morbid obesity: the SM-BOSS randomized clinical trial. Jama, 319(3), 255-265. https://jamanetwork.com/journals/jama/article-abstract/2669728
Pucci, A., Tymoszuk, U., Cheung, W. H., Makaronidis, J. M., Scholes, S., Tharakan, G., ... & Batterham, R. L. (2018). Type 2 diabetes remission 2 years post Roux‐en‐Y gastric bypass and sleeve gastrectomy: the role of the weight loss and comparison of DiaRem and DiaBetter scores. Diabetic Medicine, 35(3), 360-367. https://onlinelibrary.wiley.com/doi/full/10.1111/dme.13532
Schauer, P. R., Bhatt, D. L., Kirwan, J. P., Wolski, K., Aminian, A., Brethauer, S. A., ... & Kashyap, S. R. (2017). Bariatric surgery versus intensive medical therapy for diabetes—5-year outcomes. New England Journal of Medicine, 376(7), 641-651.Pessoa, B. M., https://www.nejm.org/doi/full/10.1056/nejmoa1600869
Simonson, D. C., Halperin, F., Foster, K., Vernon, A., & Goldfine, A. B. (2018). Clinical and patient-centered outcomes in obese patients with type 2 diabetes 3 years after randomization to Roux-en-Y gastric bypass surgery versus intensive lifestyle management: the SLIMM-T2D study. Diabetes Care, 41(4), 670-679. https://diabetesjournals.org/care/article/41/4/670/36940/Clinical-and-Patient-Centered-Outcomes-in-Obese
Still, C. D., Wood, G. C., Benotti, P., Petrick, A. T., Gabrielsen, J., Strodel, W. E., ... & Argyropoulos, G. (2014). Preoperative prediction of type 2 diabetes remission after Roux-en-Y gastric bypass surgery: a retrospective cohort study. The lancet Diabetes & endocrinology, 2(1), 38-45. https://www.thelancet.com/journals/landia/article/PIIS2213-8587(13)70070-6/fulltext
Syn, N. L., Cummings, D. E., Wang, L. Z., Lin, D. J., Zhao, J. J., Loh, M., ... & Shabbir, A. (2021). Association of metabolic–bariatric surgery with long-term survival in adults with and without diabetes: a one-stage meta-analysis of matched cohort and prospective controlled studies with 174 772 participants. The Lancet, 397(10287), 1830-1841. https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(21)00591-2/fulltext?rss=yes&s=03
Tsilingiris, D., Koliaki, C., & Kokkinos, A. (2019). Remission of type 2 diabetes mellitus after bariatric surgery: fact or fiction?. International journal of environmental research and public health, 16(17), 3171. https://www.mdpi.com/1660-4601/16/17/3171
Villena-López, E. L., Barreda-Zaleta, L., Sánchez-Luna, J. P., Isaías Camacho, J. O., Rodríguez-Weber, F. L., & Díaz-Greene, E. J. (2018). Efecto en el control glucémico y modificación del tratamiento en pacientes sometidos a cirugía bariátrica. Medicina interna de México, 34(3), 423-434. https://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S0186-48662018000300011
Yu, H., Li, Q., Zhang, M., Liu, F., Pan, J., Tu, Y., ... & Bao, Y. (2019). Decreased leptin is associated with alterations in thyroid-stimulating hormone levels after Roux-en-Y gastric bypass surgery in obese euthyroid patients with type 2 diabetes. Obesity Facts, 12(3), 272-280. https://karger.com/ofa/article/12/3/272/239613
Publicado
Cómo citar
Número
Sección
Categorías
Licencia
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
®
Los autores se comprometen a respetar la información académica de otros autores, y a ceder los derechos de autor a la Revista MQRInvestigar, para que el artículo pueda ser editado, publicado y distribuido. El contenido de los artículos científicos y de las publicaciones que aparecen en la revista es responsabilidad exclusiva de sus autores. La distribución de los artículos publicados se realiza bajo una licencia 
