Andamios en Endodoncia Regenerativa: Un Análisis de las Tendencias, Desafíos y Futuras Direcciones.
DOI:
https://doi.org/10.56048/MQR20225.8.1.2024.633-651Palabras clave:
Cultivo celular tridimensional, endodoncia regenerativa, plasma sanguíneoResumen
Esta revisión destaca la importancia de equilibrar la ingeniería de tejidos con las demandas biológicas en la endodoncia regenerativa. Se prefiere el uso de coágulos sanguíneos y concentrados de plaquetas como andamios. La variabilidad en los resultados resalta la necesidad de enfoques personalizados. Aunque se han logrado avances notables, la falta de un andamio ideal subraya la complejidad y la necesidad de investigaciones futuras. La inclusión de estudios clínicos y metaanálisis proporciona una visión completa, pero se destaca la importancia de investigaciones más rigurosas para fortalecer la evidencia científica.
La endodoncia regenerativa busca preservar la función dental mediante la revitalización pulpar. La ingeniería de tejidos, con células mesenquimáticas, factores de crecimiento y andamios, es crucial. Estos andamios, ya sean porosos o acelulares, pueden prepararse con polímeros, materiales naturales o matriz extracelular. El diseño cuidadoso del andamiaje es crucial para la adhesión, migración y diferenciación celular.
La revisión de la literatura analiza tendencias, desafíos y avances en andamios de endodoncia regenerativa. Se realizaron búsquedas en PubMed, identificando 487 artículos, de los cuales 11 fueron revisados detalladamente.
Los resultados destacan tendencias en el uso de andamios naturales como coágulos sanguíneos y concentrados de plaquetas, así como avances con biocerámicos y polímeros sintéticos. La revisión discute investigaciones clínicas, metaanálisis y estudios prospectivos que evalúan la eficacia de diversos andamios en la regeneración dentino-pulpar.
La conclusión resalta la importancia de los coágulos sanguíneos y andamios basados en plasma sanguíneo en endodoncia regenerativa, aunque señala la necesidad de más investigaciones para consolidar estos avances prometedores en el campo.
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